John M. Flack, M.D., M.P.H

 Publications in Referred Journals

1. Wiist WH, Flack JM. A Church-based Cholesterol Education Program. Public Health Reports 1990;105(4):381-388.

2. Grimm RH Jr, Flack JM, Byington R, Bond G, Brugger S. For the MIDAS Research Group. A Comparison of Antihypertensive Drug Effects on the Progression of Extracranial Carotid Atherosclerosis: The Multicenter Isradipine Diuretic Atherosclerosis Study. Drugs 1990;40 (Suppl 2):38-43.

3. Flack JM, Wiist WH. Cardiovascular Risk Factor Prevalence in African-American Adult Screenees of a Church-based Cholesterol Education Program: The Northeast Oklahoma City Cholesterol Education Program (NEOCEP). Journal of Ethnicity and Disease 1991;1:78-90.

4. Flack JM, Ensrud KE, Launer CH, Mascioli SM, Svendsen K, Elmer PJ, Grimm RH Jr . Racial and Ethnic Modifiers of the Salt Blood Pressure Response. Hypertension 1991;17(1):I-115-21.

5. Elmer PJ, Grimm RH Jr, Flack JM, Laing B. Dietary Sodium Reduction for Hypertension Prevention and Treatment in Clinical and Community Settings. Hypertension 1991;17(1)(Suppl I):I182-189.

6. Mascioli S, Launer C, Svendsen K , Flack JM, Elmer P, Grimm RH. Sodium Chloride Raises Blood Pressure in Normotensives: The Study of Sodium and Blood Pressure (SNaP). Hypertension 1991;17(1)Suppl I):I21-26.

7. Belcher JD, Egan JO, Bridgman G, Baker R, Flack JM. A Micro-Enzymatic Method to Measure Cholesterol and Triglyceride in Lipoprotein Subfractions Separated by Density Gradients Ultracentrifugation from 200 Microliters of Plasma or Serum. Journal of Lipid Research 1991;32(2):359-370.

8. McVeigh GE, Burns DE, Finkelstein SM, McDonald KM, Mock JE, Feske W, Carlyle PF, Flack JM, Grimm R, Cohn JN. Reduced Vascular Compliance as a Marker for Essential Hypertension. Am J Hypertens 1991;4:245-251.

9. Flack JM, Sowers JR. Epidemiologic and Clinical Aspects of Insulin Resistance and Hyperinsulinemia. American Journal of Medicine 1991;91(Suppl 1A):11S-21S.

10. Folsom AR, Burke GL, Byers CL, Hutchinson RG, Heiss G, Flack JM, Jacobs DR, Caan B. Implications of Obesity for Cardiovascular Disease in Blacks in the CARDIA and ARIC Studies. American Journal of Clinical Nutrition 1991;53(6 Suppl):1604S-1611S. (Published erratum appears in the American Journal of Clinical Nutrition 1991;54(3):590).

11. Flack JM, Wiist WH. Epidemiology of Hypertension and Hypertensive Target Organ Damage in the United States. Journal of the Association of Academic Minority Physicians 1991;2(4):143-150.

12. The Treatment of Mild Hypertension Research Group. A Randomized, Placebo-Controlled Trial of a Nutritional-Hygienic Regimen along with Various Drug Monotherapies. Archives of Internal Medicine 1991;151:1413-1423.

13. Bond MG, Mercuri M, Nichols FT, Khoury SA, Flack JM, Carr AA. Antiatherosclerosis Clinical Trials Using Calcium Antagonists. Journal of Vascular Medicine and Biology 1991;3(5):392-401.

14. Oparil S, Berenson GB, Esler M, Falkner B, Flack JM, Grim C, Jesse MJ, Roccella EJ, Saunders E, Weinberger M. Workshop-Epidemiology and Classification of Hypertension. Hypertension 1991;18(Supplement 3):92-94.

15. Wiist WH, Flack JM. A Test of the John Henryism Hypothesis: Cholesterol and Blood Pressure. Journal of Behavioral Medicine 1992;15(1):15-29.

16. Flack JM, Esunge P, Grimm RH. Isolated Systolic Hypertension: An Approach to Treatment. Illustrated Medicine 1992;7(1):2-16.

17. Melnick SL, Sprafka JM, Bostick RM, Flack JM, Burke GL. Antibiotic Use Patterns in Urban Whites and Blacks: The Minnesota Heart Survey. The Annals of Pharmacotherapy 1992;26(10):1292-1295.

18. Flack JM, Woolley A, Esunge P, Grimm RH Jr. A Rational Approach to Hypertension Treatment in the Older Patient. Geriatrics 1992;47(11):24-38.

19. Borhani NO, Miller ST, Brugger SB, Schnaper HW, Craven TE, Bond MG, Khoury S, Flack JM. Hypertension and Atherosclerosis. A Trial of the Effects of Antihypertensive Drug Treatment on Atherosclerosis (MIDAS). Journal of Cardiovascular Pharmacology 1992;19(Suppl 3):S16-S20.

20. Liebson PR, Grandits G, Prineas R, Dianzumba S, Flack JM, Cutler J, Grimm RH Jr, Stamler J. Echocardiographic Correlates of Left Ventricular Structure Among 844 Mild Hypertensive Men and Women in the Treatment of Mild Hypertension Study (TOMHS). Circulation 1993; 87(2):476-486.

21. Kaye SA, Folsom AR, Jacobs DR, Hughes GH, Flack JM. Psychosocial Correlates of Body Fat Distribution in Black and White Young Adults. International Journal of Obesity 1993;17:271-277.

22. Flack JM, Neaton JD, Daniels B, Esunge P. Ethnicity and Renal Disease: Lessons from Multiple Risk Factor Intervention Trial and the Treatment of Mild Hypertension Study. American Journal of Kidney Diseases 1993;21(4 Suppl I):31-40.

23. Flack JM, McVeigh GE, Grimm RH Jr. Hypertension Therapy in the Elderly. Current Opinion in Nephrology 1993;2:386-394.

24. Bradley K, Flack JM, Belcher J, Elmer P, Miller P, Grimm RH Jr. Chlorthalidone Attenuates the Reduction in Total Cholesterol and Small, Dense LDL Cholesterol Subclass Associated With Weight Loss. Am J Hypertens 1993;6:636-39.

25. Neaton JD, Grimm RH Jr., Prineas RJ, Stamler J, Grandits GA, Elmer PJ, Cutler JA, Flack JM, Schoenberger JA, McDonald R, Lewis CE, Liebson PR. Treatment of Mild Hypertension Study (TOMHS) Final Results. Journal of the American Medical Association 1993;270:713-724.

26. Wilt TJ, Sprinkle JW, Flack JM, Heuer C, Borhani N, Merchant A, Schnaper HW, Applegate W, Grimm RH Jr. Prevalence and Correlates of Lower Extremity Arterial Disease in Hypertensive Patients with Carotid Atherosclerosis:Baseline Results from the Multicenter Isradipine/Diuretic Atherosclerosis Study (MIDAS). Journal of Vascular Medicine and Biology 1993;4:95-101.

27. Perloff D, Grim C, Flack JM, Frohlich ED, Hill M, McDonald M, Morgenstern BZ. Writing Group. Human Blood Pressure Determination by Sphygmomanometry. Circulation 1993;88(5 Part 1):2460-2470.

28. Folsom AR, Qamheih HT, Flack JM, Hilner JE, Liu K, Howard BV, Tracy RP. Plasma Fibrinogen: Levels and Correlates of Young Adults. The Coronary Artery Risk Development in Young Adults (CARDIA) Study. American Journal of Epidemiology 1993;138(12);1023-1036.

29. Mercuri M, Bond MG, Nichols FT, Carr AA, Flack JM, Byington R, Raines J. For the MIDAS Group. Baseline Reproductivity of B-Mode Ultrasound Imaging Measurements of Cartoid Intima Media Thickness: The Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS). Journal of Cardiovascular Diagnosis and Procedures 1993;2(4):241-256.

30. Kvasnicka J, Flack JM, Grimm RH Jr. Treatment of Hypertension in the Presence of Coexisting Medical Conditions. Drugs & Aging 1994;4(4): 304-312.

31. Flack JM. High Blood Pressure in Older Persons: A High Risk Special Population. Canadian Journal of Public Health 1994;85(Suppl 2):S9-11

32. Wright JT Jr., Flack JM. Diuretics - What Role For Reduction of Cardiovascular Disease Risk in African Americans? Cholesterol and Coronary Disease... Reducing the Risk 1994;5(1):15-18.

33. Abraham PA, Mascioli SR, Launer CA, Flack JM, Liebson PR, Svendson KH, Grandits GA, Opsahl JA, Schoenberger JA, Grimm RH Jr. Urinary Albumin and N-Acetyl-Beta-D-Glucosaminidase Excretions in Mild Hypertension. Am J Hypertens 7:965-974, 1994.

34. Howard BV, Le NA, Belcher JD, Flack JM, Jacobs DR Jr, Lewis CE, Marcovina SM, Perkins LL. Concentrations of Lp(a) in Black and White Young Adults: Relations to Risk Factors for Cardiovascular Disease. Annals of Epidemiology 4(5):341-350 1994.

35. Flack JM, Ryder KW, Strickland D, Whang R. Metabolic Correlates of Theophylline Therapy - A Concentration-Related Phenommena. Annals of Pharmacotherapy 1994,28:175-179.

36. Flack JM. Systolic Hypertension: Worth Treating? The Kidney 1995;1(1).

37. McVeigh G, Flack JM, Grimm RH Jr. Goals of Antihypertensive Therapy. Drugs 1995;49 (2): 161-175.

38. Flack JM. Linking The Medical And Public Health Approaches For The Prevention, Management, And Control Of Hypertension In The African-American Population: What Steps Can We Take Today. Journal of the National Medical Association 1995;87(8 Suppl):657-658).

39. Rinehart AL, Herzog CA, Collins AJ, Flack JM, Ma JZ, Opsahl JA. A Comparison of Coronary Angioplasty and Coronary Artery Bypass Grafting Outcomes in Chronic Dialysis Patients. American Journal of Kidney Diseases 1995;25(2):281-290.

40. Hoegerman GS, Lewis CE, Flack JM, Raczynski JM, Caveny J, Gardin, JM. Lack of Association of Recreational Cocaine and Alcohol Use With Left Ventricular Mass in Young Adults. The Coronary Artery Risk Development in Young Adults (CARDIA) Study. J Am Coll Cardiol 1995;25(4):895-900.

41. Flack JM, Amaro H, Jenkins W, Kunitz S, Levy J, Mixon M, Yu E. Epidemiology of Minority Health. Health Psychology 1995;14(7):592-600.

42. Zhang S, Folsom A, Flack JM, Liu K. Body Fat Distribution Before Pregnancy and Gestational Diabetes: Findings From Coronary Artery Risk Development In Young Adults (CARDIA) Study. BMJ 1995;311:1139-1140.

43. Flack JM, Neaton J, Grimm RH Jr, Cutler J, Shih J, Ensrud K, MacMahon S. Blood Pressure and Mortality Among Men with Prior Myocardial Infarction. Circulation 1995;92:2437-2445.

44. Flack JM, Mensah, McVeigh GE, Weir M, Reed J. Diagnosis, Evaluation and Management of Hypertension in an Ambulatory Clinic Setting. Journal of Clinical Outcomes Management 1995;2(5):1-21.

45. Grimm RH Jr, Flack JM, Schoenberger J, Gonzalez N, Liebson P. Alpha Blockade and Thiazide Treatment of Hypertension: A Double-Blind Randomized Trial Comparing Doxazosin and Hydrochlorothiazide. Am J Hypertens. 1996 May;9(5):445-454.

46. Jones-Webb R, Jacobs DR, Flack JM, Liu K. Relationships Between Depressive Symptoms, Anxiety, Alcohol Consumption, and Blood Pressure: Results from the CARDIA Study. Journal of Alcoholism: Clinical and Experimental Research. Alcohol Clin Exp Res. 1996 May;20(3):420-427.

47. Gidding SS, Xie X, Liu K, Manolio T, Flack JM, Gardin JM,. Cardiac Function in Smokers and Nonsmokers. The CARDIA Study. Journal of the American College of Cardiology 26(1):211-216. 1995

48. Weir M, Bakris G, Toto R, Flack JM, Williams B, Neutel J. Hypertension. Current Nephrology, 1996;19:203-241

49. Liu K, Ruth KJ, Flack JM, Jones-Webb R, Burke G, Savage PJ, Hulley SB. Blood Pressure in Young Black and Whites: Relevance of Obesity and Lifestyle Factors in Determining Differences -- The CARDIA Study. Circulation 93(1):60-66,1996 Jan 1.

50. Flack JM. Benefits of Adherence to Antihypertensive Drug Therapy. European Heart Journal 1996;(17-A):16-20.

51. Lewis CE, Grandits GA, Flack JM, McDonald R, Elmer PJ, for the Treatment of Mild Hypertension Study Research Group. Efficacy and Tolerance of Antihypertensive Treatment in Men and Women With Stage 1 Diastolic Hypertension. Archives of Internal Medicine 1996;156:377-385.

52. Ferrario CM, Flack JM. Pathological Consequences of Increased Angiotensin II Activity. Cardiovascular Drugs and Therapy. 1996;10:511-518.

53. Folsom AR, Jacobs Jr DR, Wagenknecht LE, Winkhart SP, Yunis C, Hilner JE, Savage PJ, Smith DE, Flack JM. Increase In Fasting Insulin And Glucose Over Seven Years With Increasing Weight And Inactivity Of Young Adults. The CARDIA Study. American Journal of Epidemiology 1996;144:235-246.

54. Weir MR, Flack JM, Applegate WB. Tolerability, Safety and Quality of Life and Hypertensive Therapy: The Case for Low Dose Diuretics. Am J Med 1996;101(Suppl 3A):83S-92S.

55. Gidding SS, Liu K, Bild DE, Flack JM, Gardin J, Ruth KJ, Oberman, A. Prevalence And Identification Of Abnormal Lipoprotein Levels In A Biracial Population Aged 23 To 35 Years (the CARDIA Study). The Coronary Artery Risk Development in Young Adults Study. American Journal of Cardiology 1996;78(3):304-308.

56. Flack JM, Cushman W. Evidence Of The Efficacy Of Low-Dose Diuretic Monotherapy. Am J Med 1996;101(Suppl 3A):53S-60S.

57. Markovitz JH, Raczynski JM, Lewis CE, Flack JM, Chesney M, Chettur V, Hardin JM, Johnson E. Lack Of Independent Relationships Between Left Ventricular Mass And Cardiovascular Reactivity To Physical And Psychological Stress In The Coronary Artery Risk Development In Young Adults (CARDIA) Study. Am J Hypertens 1996;9(9):915-923.

58. Flack JM, Yunis C. Therapeutic Implications Of The Epidemiology And Timing Of Myocardial Infarction And Other Cardiovascular Diseases. J Hum Hypertens 1997 Jan;11(1):23-8 Review.

59. National High Blood Pressure Education Program. 1995 Update of the Working Group Reports on Chronic Renal Failure and Renovascular Hypertension. Arch Intern Med 1996 Sep 23;156(17):1938-47.

60. Maron BJ, Gardin JM, Flack JM, Gidding SS, Bild DE. HCM In The General Population. Circulation 1996;94(3):588-589.

61. Grimm RH Jr, Grandits GA, Prineas RJ, McDonald RH, Lewis CE, Flack JM, Yunis C, Svendsen K, Liebson PR, Elmer PJ, Stamler J, for the TOMHS Research Group. Long-term Effects on Sexual Function of Five Antihypertensive Drugs and Nutritional Hygienic Treatment in Hypertensive Men and Women. Treatment of Mild Hypertension Study (TOMHS). Hypertension 1997;29:8-14.

62. Weir MR, Hall PS, Behrens MT, Flack JM. Salt And Blood Pressure Responses To Calcium Antagonism In Hypertensive Patients. Hypertension 1997;30(3 Pt. 1):422-427.

63. Hall WD, Ferrario CM, Moore MA, Hall JE, Flack JM, Cooper W, Simmons JD, Egan BM, Lackland DT, Perry M, Jr., Roccella EJ. Hypertension-Related Morbidity and Mortality in Southeastern United States: The American Journal of the Medical Sciences 1997. Am J Med Sci. 1997 Apr;313(4):195-209.

64. Members of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Archives of Internal Medicine November 24, 1997;157:2413-2446.

65. Ganguli MC, Grimm RH Jr, Svendsen KH, Flack JM, Grandits GA, Elmer PJ Higher education and income are related to a better Na:K ratio inblacks: baseline results of the Treatment of Mild Hypertension Study (TOMHS) data. Am J Hypertens 1997 Sep;10(9 Pt 1):979-84

66. Deitch JS, Hansen KJ, Craven TE, Flack JM, Appel RG, Dean RH. Renal artery repair in African-Americans. J Vasc Surg 1997 Sep;26(3):465-72; discussion 473

67. Flack JM, Hamaty M., Staffileno, BA. Renin-Angiotensin-Aldosterone-Kinin (RAAK) System Influences on Diabetic Vascular Disease and Cardiomyopathy. Mineral and Electrolyte Metabolism 1998;24(6):412-22

68. Ferrario CM, Martel N, Yunis C, Flack JM, Chappell MC, Brosnihan KB, Dean RH, Fernandez A, Novikov SV, Pinillas C, Luque M. Characterization of Angiotensin-(1-7) in the Urine of Normal and Essential Hypertensive Subjects. Am J Hypertens 1998 Feb; 11(2):137-146

69. Ganguli MC, Grimm RH Jr, Svendsen KH, Flack JM, Grandits GA, Elmer PJ. Urinary sodium and potassium profile of blacks and whites in relation to education in two different geographic urban areas. TOMHS Research Group. Treatment of Mild Hypertension Study. Am J Hypertens 1999 Jan;12(1 Pt 1):69-72

70. Hall WD, Reed JW, Flack JM, Yunis C, Preisser J for the ISHIB Investigators Group. Comparison of the Efficacy of Dihydropyridine Calcium Antagonists in African-American Hypertensives. Arch Intern Med 1998 Oct 12;158(18):2029-34